Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K12 | Q12852 | 20/20 | 0.59 |
| ▸ | DLK1 | P80370 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16220306 | 0.92 | MAP3K12 (0.69) | MAP3K12 | |
| SCHEMBL16220425 | 0.88 | MAP3K12 (0.71) | MAP3K12 | |
| SCHEMBL16220289 | 0.88 | MAP3K12 (0.73) | MAP3K12 | |
| SCHEMBL16220304 | 0.87 | MAP3K12 (0.54) | MAP3K12 | |
| SCHEMBL19771675 | 0.87 | MAP3K12 (0.54) | MAP3K12 | |
| SCHEMBL22239495 | 0.87 | MAP3K12 (0.54) | MAP3K12 | |
| SCHEMBL16220222 | 0.85 | MAP3K12 (0.77) | MAP3K12DLK1 | |
| SCHEMBL16220476 | 0.84 | MAP3K12 (0.69) | MAP3K12 | |
| SCHEMBL16220229 | 0.82 | MAP3K12 (0.86) | MAP3K12 | |
| SCHEMBL16220310 | 0.82 | MAP3K12 (0.82) | MAP3K12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2991977-B1 | C-LINKED HETEROCYCLOALKYL SUBSTITUTED PYRIMIDINES AND THEIR USES | HOFFMANN LA ROCHE (CH) | 2020-07-22 | — | — | EP | disclosed |
| WO-2014177524-A1 | C-LINKED HETEROCYCLOALKYL SUBSTITUTED PYRIMIDINES AND THEIR USES | F. HOFFMANN-LA ROCHE AG (CH) | 2014-11-06 | — | — | WO | disclosed |