Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.51 |
| ▸ | CTSD | P07339 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2382064 | 0.85 | BACE1 (0.77) | BACE1KCNH2CTSD | |
| SCHEMBL2525084 | 0.85 | BACE1 (0.77) | BACE1KCNH2CTSD | |
| SCHEMBL2372051 | 0.85 | BACE1 (0.70) | BACE1KCNH2CTSD | |
| SCHEMBL2372044 | 0.85 | BACE1 (0.70) | BACE1KCNH2CTSD | |
| SCHEMBL2522932 | 0.83 | BACE1 (0.61) | BACE1KCNH2 | |
| SCHEMBL2371491 | 0.83 | BACE1 (0.59) | BACE1KCNH2 | |
| SCHEMBL2382000 | 0.83 | BACE1 (0.61) | BACE1KCNH2 | |
| SCHEMBL2371496 | 0.83 | BACE1 (0.59) | BACE1KCNH2 | |
| SCHEMBL2522951 | 0.81 | BACE1 (0.56) | BACE1KCNH2CTSD | |
| SCHEMBL2521397 | 0.80 | BACE1 (0.59) | BACE1KCNH2CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8883782-B2 | Spiro-tetracyclic ring compounds as beta-secretase modulators and methods of use | AMGEN INC. (US) | 2014-11-11 | — | — | US | disclosed |