Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.54 |
| ▸ | CTSD | P07339 | 5/20 | 0.51 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2517640 | 0.85 | BACE1 (0.48) | BACE1KCNH2CTSDBACE2 | |
| SCHEMBL3280697 | 0.82 | BACE1 (0.53) | BACE1KCNH2CTSD | |
| SCHEMBL15510563 | 0.82 | BACE1 (0.77) | BACE1KCNH2CTSD | |
| SCHEMBL3273353 | 0.82 | BACE1 (0.77) | BACE1KCNH2CTSD | |
| SCHEMBL2370976 | 0.81 | BACE1 (0.58) | BACE1KCNH2CTSD | |
| SCHEMBL3280692 | 0.78 | BACE1 (0.58) | BACE1KCNH2CTSD | |
| SCHEMBL2371763 | 0.75 | BACE1 (0.71) | BACE1KCNH2CTSD | |
| SCHEMBL2384399 | 0.75 | BACE1 (0.72) | BACE1KCNH2CTSD | |
| SCHEMBL15510045 | 0.74 | BACE1 (0.72) | BACE1KCNH2CTSDBACE2 | |
| SCHEMBL2525044 | 0.73 | BACE1 (0.58) | BACE1KCNH2CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8883782-B2 | Spiro-tetracyclic ring compounds as beta-secretase modulators and methods of use | AMGEN INC. (US) | 2014-11-11 | — | — | US | disclosed |