Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16224167 | 1.00 | ACACB (0.34) | ACACBPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL16224069 | 1.00 | ACACB (0.34) | ACACBPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL16224179 | 1.00 | ACACB (0.34) | ACACBPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL16224108 | 1.00 | ACACB (0.34) | ACACBPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL16224003 | 0.97 | ACACB (0.32) | ACACBPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL16223961 | 0.97 | ACACB (0.32) | ACACBPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL16224148 | 0.97 | ACACB (0.32) | ACACBPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL16223962 | 0.97 | ACACB (0.32) | ACACBPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL16224181 | 0.97 | ACACB (0.32) | ACACBPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9897423 | 0.94 | PDE4A (0.33) | ACACBPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8927557-B2 | Methylpyrrolopyrimidinecarboxamides | TAKEDA GMBH (DE) | 2015-01-06 | — | — | US | disclosed |
| EP-2470536-B1 | Methylpyrrolopyrimidinecarboxamides | TAKEDA GMBH (DE) | 2014-11-12 | — | — | EP | disclosed |