Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1L1 | Q9UHC9 | 4/20 | 0.66 |
| ▸ | CDC25A | P30304 | 3/20 | 0.62 |
| ▸ | CDC25B | P30305 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | INPP5D | Q92835 | 1/20 | 0.60 |
| ▸ | SRD5A1 | P18405 | 4/20 | 0.57 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.57 |
| ▸ | FNTA | P49354 | 2/20 | 0.57 |
| ▸ | FNTB | P49356 | 2/20 | 0.57 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.55 |
| ▸ | OSBP | P22059 | 1/20 | 0.55 |
| ▸ | RORC | P51449 | 1/20 | 0.55 |
| ▸ | OSBP2 | Q969R2 | 1/20 | 0.55 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7117470 | 1.00 | NPC1L1 (0.66) | NPC1L1CDC25ACDC25BCYP2D6CYP2C19 | |
| SCHEMBL16226011 | 1.00 | NPC1L1 (0.66) | NPC1L1CDC25ACDC25BCYP2D6CYP2C19 | |
| SCHEMBL7117472 | 1.00 | NPC1L1 (0.66) | NPC1L1CDC25ACDC25BCYP2D6CYP2C19 | |
| SCHEMBL16225645 | 1.00 | NPC1L1 (0.66) | NPC1L1CDC25ACDC25BCYP2D6CYP2C19 | |
| SCHEMBL16226436 | 1.00 | NPC1L1 (0.66) | NPC1L1CDC25ACDC25BCYP2D6CYP2C19 | |
| SCHEMBL25336952 | 0.92 | NPC1L1 (0.56) | NPC1L1CDC25ACDC25BCYP2D6CYP2C19 | |
| SCHEMBL17817531 | 0.89 | PTPN1 (0.71) | NPC1L1CDC25ACDC25BCYP2D6CYP2C19 | |
| SCHEMBL26642635 | 0.89 | PTPN1 (0.71) | NPC1L1CDC25ACDC25BCYP2D6CYP2C19 | |
| SCHEMBL17817532 | 0.89 | PTPN1 (0.71) | NPC1L1CDC25ACDC25BCYP2D6CYP2C19 | |
| SCHEMBL26642641 | 0.89 | PTPN1 (0.71) | NPC1L1CDC25ACDC25BCYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140335050-A1 | METHODS, COMPOSITIONS, AND KITS FOR THE TREATMENT OF CANCER | THE GENERAL HOSPITAL CORPORATION (US) | 2014-11-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140335050-A1 | METHODS, COMPOSITIONS, AND KITS FOR THE TREATMENT OF CANCER | IL2RA, CD74, IL2 | NPC1L1 4118/4885CDC25A 334/4885CDC25B 1240/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.