Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Methacrylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | CA4 | P22748 | 2/20 | 0.39 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | PEPD | P12955 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methacrylic Acid SCHEMBL28161362 | 1.00 | CA1 (0.53) | CA1TDP1CA4FFAR3LCK | |
| Methacrylic Acid SCHEMBL28161417 | 0.97 | CA1 (0.50) | CA1TDP1CA4FFAR3LCK | |
| Methacrylic Acid SCHEMBL1621313 | 0.93 | CA1 (0.53) | CA1TDP1CA4FFAR3LCK | |
| Methacrylic Acid SCHEMBL28161875 | 0.93 | CA1 (0.53) | CA1TDP1CA4FFAR3LCK | |
| Methacrylic Acid SCHEMBL1623650 | 0.93 | CA1 (0.53) | CA1TDP1CA4FFAR3LCK | |
| Methacrylic Acid SCHEMBL3224823 | 0.90 | CA4 (0.44) | CA1TDP1CA4FFAR3LCK | |
| Methacrylic Acid SCHEMBL28161349 | 0.90 | CA1 (0.50) | CA1TDP1CA4FFAR3LCK | |
| Methacrylic Acid SCHEMBL11359770 | 0.87 | CA1 (0.50) | CA1TDP1CA4FFAR3LCK | |
| Methacrylic Acid SCHEMBL28193258 | 0.87 | CA1 (0.44) | CA1TDP1CA4FFAR3LCK | |
| Methacrylic Acid SCHEMBL3980981 | 0.86 | TDP1 (0.47) | CA1TDP1FFAR3LCKFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7928175-B2 | Antifouling paint composition | MITSUBISHI RAYON CO., LTD. (JP) | 2011-04-19 | — | — | US | disclosed |
| US-7553481-B2 | Underwater antifouling coating composition with excellent storage stability | API CORPORATION (JP) | 2009-06-30 | — | — | US | disclosed |
| US-20060258772-A1 | Antifouling paint composition | MITSUBISHI RAYON CO. LTD. (JP) | 2006-11-16 | — | — | US | disclosed |