Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 13/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | TYMP | P19971 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
| ▸ | HEXA | P06865 | 1/20 | 0.30 |
| ▸ | HEXB | P07686 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12496379 | 0.80 | TLR8 (0.47) | TLR8TLR7KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL12495729 | 0.79 | ADORA2A (0.46) | TLR8KDM4EHPGDNPSR1 | |
| SCHEMBL12495846 | 0.76 | TLR8 (0.54) | TLR8TLR7KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL12495995 | 0.76 | HEXA (0.48) | TLR8SMN1; SMN2HEXAHEXB | |
| SCHEMBL28043913 | 0.75 | TLR8 (0.44) | TLR8TLR7KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL6416413 | 0.75 | TLR8 (0.56) | TLR8TLR7NPSR1 | |
| SCHEMBL12496008 | 0.75 | GCGR (0.43) | TLR8TLR7KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL3830025 | 0.75 | TLR8 (0.49) | TLR8TLR7KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL12495463 | 0.73 | TLR8 (0.47) | TLR8TLR7KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL16229331 | 0.72 | TLR8 (0.41) | TLR8TLR7KDM4EHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3195867-A1 | PYRIMIDINE COMPOUNDS INHIBITING THE FORMATION OF NITRIC OXIDE AND PROSTAGLANDIN E2, METHOD OF PRODUCTION THEREOF AND USE THEREOF | Ustav Organicke Chemie A Biochemie Akademie Ved Cr, v.v.i. (CZ) | 2017-07-26 | — | — | EP | disclosed |
| US-8883798-B2 | Pyrimidine compounds inhibiting the formation of nitric oxide and prostaglandin E2, method of production thereof and use thereof | USTAV ORGANICKE CHEMIE A BIOCHEMIE AKADEMIE VED CR, v.v.i. (CZ) | 2014-11-11 | — | — | US | disclosed |
| US-8883798-B2 | Pyrimidine compounds inhibiting the formation of nitric oxide and prostaglandin E2, method of production thereof and use thereof | USTAV ORGANICKE CHEMIE A BIOCHEMIE AKADEMIE VED CR, v.v.i. (CZ) | 2014-11-11 | — | — | US | disclosed |