Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 2/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.37 |
| ▸ | FGFR2 | P21802 | 5/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 5/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.37 |
| ▸ | CDK7 | P50613 | 3/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 7/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 7/20 | 0.36 |
| ▸ | CDK1 | P06493 | 6/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 6/20 | 0.36 |
| ▸ | CDK2 | P24941 | 5/20 | 0.36 |
| ▸ | KDR | P35968 | 4/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1645504 | 0.86 | PDPK1 (0.44) | PDPK1FGFR1FGFR2FGFR3CHEK1 | |
| SCHEMBL12519666 | 0.81 | PDPK1 (0.39) | PDPK1FGFR1FGFR2FGFR3CHEK1 | |
| SCHEMBL13545069 | 0.79 | FGFR1 (0.39) | PDPK1PARP1FGFR1FGFR2FGFR3 | |
| SCHEMBL12303918 | 0.77 | PDPK1 (0.44) | PDPK1FGFR1FGFR2FGFR3CHEK1 | |
| SCHEMBL13545065 | 0.77 | PDPK1 (0.43) | PDPK1PARP1FGFR1FGFR2FGFR3 | |
| SCHEMBL11037651 | 0.76 | PARP1 (0.52) | PDPK1PARP1FGFR1FGFR2FGFR3 | |
| SCHEMBL14780745 | 0.75 | AURKA (0.43) | PDPK1PARP1FGFR1FGFR2FGFR3 | |
| SCHEMBL13545037 | 0.75 | AURKA (0.43) | PDPK1FGFR1FGFR2FGFR3CHEK1 | |
| SCHEMBL14922198 | 0.74 | AURKA (0.44) | PDPK1PARP1FGFR1FGFR2FGFR3 | |
| SCHEMBL13545041 | 0.74 | MAPT (0.43) | PDPK1FGFR1FGFR2FGFR3CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8883790-B2 | Pharmaceutical combinations | ASTEX THERAPEUTICS LIMITED (GB) | 2014-11-11 | — | — | US | disclosed |
| US-8883790-B2 | Pharmaceutical combinations | ASTEX THERAPEUTICS LIMITED (GB) | 2014-11-11 | — | — | US | disclosed |