Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.76 |
| ▸ | PDE6C | P51160 | 2/20 | 0.57 |
| ▸ | PDE6D | O43924 | 1/20 | 0.55 |
| ▸ | PDE6A | P16499 | 1/20 | 0.55 |
| ▸ | PDE6G | P18545 | 1/20 | 0.55 |
| ▸ | PDE6B | P35913 | 1/20 | 0.55 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4990471 | 0.87 | PDE5A (0.84) | PDE5APDE6CPDE6DPDE6APDE6G | |
| SCHEMBL4994864 | 0.87 | PDE5A (0.83) | PDE5APDE6CPDE6DPDE6APDE6G | |
| SCHEMBL4989397 | 0.87 | PDE5A (1.00) | PDE5APDE6CPDE6DPDE6APDE6G | |
| SCHEMBL6853469 | 0.86 | PDE5A (0.75) | PDE5APDE6CPDE6DPDE6APDE6G | |
| SCHEMBL5595728 | 0.85 | PDE5A (0.80) | PDE5APDE6CPDE6DPDE6APDE6G | |
| SCHEMBL5595570 | 0.85 | PDE5A (0.80) | PDE5APDE6CPDE6DPDE6APDE6G | |
| SCHEMBL4983571 | 0.85 | PDE5A (0.81) | PDE5APDE6CPDE6DPDE6APDE6G | |
| SCHEMBL5595604 | 0.84 | PDE5A (0.79) | PDE5APDE6CPDE6DPDE6APDE6G | |
| SCHEMBL4989622 | 0.84 | PDE5A (0.80) | PDE5APDE6CPDE6DPDE6APDE6G | |
| SCHEMBL5595920 | 0.84 | PDE5A (0.75) | PDE5APDE6CPDE6DPDE6APDE6G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379076-B1 | PHOSPHODIESTERASE INHIBITORS AND USES THEREOF | UNIV COLUMBIA (US) | 2014-11-12 | — | — | EP | disclosed |