Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 10/20 | 0.72 |
| ▸ | PDE7B | Q9NP56 | 5/20 | 0.72 |
| ▸ | PDE8A | O60658 | 3/20 | 0.54 |
| ▸ | CASR | P41180 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL99700 | 0.95 | PDE7A (0.79) | PDE7APDE7BPDE8ACASRMAPT | |
| SCHEMBL7883412 | 0.85 | PDE7A (0.66) | PDE7APDE7BPDE8AMAPTMEN1 | |
| SCHEMBL581681 | 0.85 | PDE7A (0.79) | PDE7APDE7BPDE8ACASRALDH1A1 | |
| SCHEMBL30837814 | 0.84 | PDE7A (0.82) | PDE7APDE7BPDE8ACASRMAPT | |
| SCHEMBL2681821 | 0.84 | PDE7A (0.82) | PDE7APDE7BPDE8ACASRMAPT | |
| SCHEMBL100526 | 0.84 | PDE7A (0.64) | PDE7APDE7BPDE8AMAPTMEN1 | |
| SCHEMBL30837824 | 0.84 | PDE7A (0.80) | PDE7APDE7BPDE8ACASRALDH1A1 | |
| SCHEMBL99689 | 0.84 | PDE7A (0.80) | PDE7APDE7BPDE8ACASRALDH1A1 | |
| SCHEMBL99715 | 0.84 | PDE7A (0.80) | PDE7APDE7BPDE8AMAPTMEN1 | |
| SCHEMBL100515 | 0.83 | PDE7A (0.66) | PDE7APDE7BPDE8AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2416777-B1 | THERAPEUTIC APPLICATIONS IN THE CARDIOVASCULAR FIELD OF QUINAZOLINEDIONE DERIVATIVES | SANOFI SA (FR) | 2014-11-12 | — | — | EP | disclosed |