Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 17/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1328660 | 0.79 | GCK (0.56) | GCKKDM4ENPC1HTTRAB9A | |
| SCHEMBL1329911 | 0.78 | GCK (0.46) | GCKKDM4ENPC1HTTRAB9A | |
| SCHEMBL1328809 | 0.76 | GCK (0.64) | GCKRAB9A | |
| SCHEMBL1330791 | 0.74 | GCK (0.53) | GCKKDM4ENPC1HTTRAB9A | |
| SCHEMBL2341148 | 0.73 | GCK (0.59) | GCKKDM4ENPC1HTTRAB9A | |
| SCHEMBL1329654 | 0.73 | GCK (0.57) | GCKNPC1RAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL1330143 | 0.72 | GCK (0.58) | GCKKDM4ENPC1HTTRAB9A | |
| SCHEMBL16467487 | 0.71 | GCK (0.47) | GCKKDM4ENPC1HTTRAB9A | |
| SCHEMBL1331445 | 0.71 | GCK (0.52) | GCKKDM4ENPC1HTTRAB9A | |
| SCHEMBL1330706 | 0.70 | GCK (0.48) | GCKKDM4ENPC1HTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8883828-B2 | 2-aminopyridine analogs as glucokinase activators | ARRAY BIOPHARMA INC. (US) | 2014-11-11 | — | — | US | disclosed |