Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 6/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.40 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | GALR3 | O60755 | 1/20 | 0.34 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16235405 | 0.81 | GPBAR1 (0.37) | PTGS1PTGS2ALDH1A1GPBAR1MEN1 | |
| SCHEMBL10636894 | 0.71 | FSCN1 (0.41) | PTGS1PTGS2FSCN1ALDH1A1POLB | |
| SCHEMBL16235142 | 0.70 | GPBAR1 (0.34) | PTGS1PTGS2ALDH1A1GPBAR1MEN1 | |
| SCHEMBL16914887 | 0.69 | FSCN1 (0.51) | FSCN1TSHRHSD17B10ALDH1A1POLB | |
| SCHEMBL10559944 | 0.67 | CYP3A4 (0.58) | POLBMEN1KMT2A | |
| SCHEMBL5394112 | 0.62 | FSCN1 (0.41) | PTGS1PTGS2FSCN1TSHRHSD17B10 | |
| SCHEMBL5342714 | 0.62 | SMN1; SMN2 (0.56) | FSCN1TSHRALDH1A1POLBMEN1 | |
| SCHEMBL16235332 | 0.62 | ERCC1 (0.51) | PTGS1PTGS2HSD17B10ALDH1A1GALR3 | |
| SCHEMBL11560828 | 0.61 | FSCN1 (0.54) | FSCN1TSHRHSD17B10ALDH1A1POLB | |
| SCHEMBL1569720 | 0.59 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925743-A1 | N-(HETEROARYL)-SULFONAMIDE DERIVATIVES USEFUL AS S100-INHIBITORS | Active Biotech AB (SE) | 2015-10-07 | — | — | EP | claimed |
| WO-2014184234-A1 | N-(HETEROARYL)-SULFONAMIDE DERIVATIVES USEFUL AS S100-INHIBITORS | ACTIVE BIOTECH AB (SE) | 2014-11-20 | — | — | WO | claimed |
| EP-2925743-A1 | N-(HETEROARYL)-SULFONAMIDE DERIVATIVES USEFUL AS S100-INHIBITORS | Active Biotech AB (SE) | 2015-10-07 | — | — | EP | disclosed |
| WO-2014184234-A1 | N-(HETEROARYL)-SULFONAMIDE DERIVATIVES USEFUL AS S100-INHIBITORS | ACTIVE BIOTECH AB (SE) | 2014-11-20 | — | — | WO | disclosed |