Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 2/20 | 0.31 |
| ▸ | AURKA | O14965 | 4/20 | 0.30 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16754609 | 0.92 | ALK (0.31) | ALKAURKAAURKB | |
| SCHEMBL16249999 | 0.92 | ALK (0.31) | ALKAURKAAURKB | |
| SCHEMBL16238397 | 0.82 | AURKA (0.37) | ALKAURKAAURKB | |
| SCHEMBL21841339 | 0.81 | AURKA (0.32) | ALKAURKAAURKB | |
| SCHEMBL16238490 | 0.80 | AURKA (0.40) | ALKAURKAAURKB | |
| SCHEMBL17624523 | 0.79 | AURKA (0.32) | ALKAURKAAURKB | |
| SCHEMBL16238555 | 0.78 | NOTUM (0.46) | ALKAURKAAURKB | |
| SCHEMBL16249982 | 0.77 | AURKA (0.38) | ALKAURKAAURKB | |
| Trifluoroacetic Acid SCHEMBL16238799 | 0.76 | NOTUM (0.44) | ALKAURKAAURKB | |
| SCHEMBL16238759 | 0.76 | CA12 (0.42) | ALKAURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997029-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | Glaxosmithkline LLC (US) | 2016-03-23 | — | — | EP | disclosed |
| WO-2014186313-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2014-11-20 | — | — | WO | disclosed |