Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 4/20 | 0.43 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.35 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1623930 | 1.00 | KMT2A (0.43) | KMT2AMEN1CHEK2SMAD3ALDH1A1 | |
| SCHEMBL1623833 | 0.91 | MEN1 (0.42) | KMT2AMEN1CHEK2SMAD3ALDH1A1 | |
| SCHEMBL1623832 | 0.91 | MEN1 (0.42) | KMT2AMEN1CHEK2SMAD3ALDH1A1 | |
| SCHEMBL1621281 | 0.87 | MEN1 (0.49) | KMT2AMEN1CHEK2SMAD3ALDH1A1 | |
| SCHEMBL1621278 | 0.87 | MEN1 (0.49) | KMT2AMEN1CHEK2SMAD3ALDH1A1 | |
| SCHEMBL1623555 | 0.87 | MEN1 (0.49) | KMT2AMEN1CHEK2SMAD3ALDH1A1 | |
| Hydrochloric Acid SCHEMBL1623542 | 0.86 | MEN1 (0.48) | KMT2AMEN1CHEK2SMAD3ALDH1A1 | |
| Hydrochloric Acid SCHEMBL1623544 | 0.86 | MEN1 (0.48) | KMT2AMEN1CHEK2SMAD3ALDH1A1 | |
| Hydrochloric Acid SCHEMBL1624026 | 0.86 | MEN1 (0.48) | KMT2AMEN1CHEK2SMAD3ALDH1A1 | |
| SCHEMBL1621759 | 0.85 | MAPT (0.41) | KMT2AMEN1CHEK2SMAD3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8283354-B2 | Voltage gated sodium and calcium channel inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-10-09 | — | — | US | disclosed |
| US-7928107-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-04-19 | — | — | US | disclosed |