Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diethylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 20/20 | 0.64 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.59 |
| ▸ | SCN2B | O60939 | 1/20 | 0.59 |
| ▸ | SCN1A | P35498 | 1/20 | 0.59 |
| ▸ | SCN1B | Q07699 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14892882 | 0.96 | SCN9A (0.69) | SCN9ASCN5ASCN2BSCN1ASCN1B | |
| SCHEMBL16239622 | 0.89 | SCN9A (0.76) | SCN9ASCN5ASCN2BSCN1ASCN1B | |
| Diethylamine SCHEMBL16239701 | 0.88 | SCN9A (0.58) | SCN9ASCN5ASCN2BSCN1ASCN1B | |
| Diethylamine SCHEMBL16178014 | 0.84 | SCN9A (0.68) | SCN9ASCN5ASCN2BSCN1ASCN1B | |
| SCHEMBL364874 | 0.83 | SCN9A (0.62) | SCN9ASCN5ASCN2BSCN1ASCN1B | |
| SCHEMBL16174929 | 0.82 | SCN9A (0.86) | SCN9ASCN5ASCN2BSCN1ASCN1B | |
| SCHEMBL15036783 | 0.79 | SCN9A (0.73) | SCN9ASCN5ASCN2BSCN1ASCN1B | |
| SCHEMBL16239561 | 0.79 | SCN9A (0.64) | SCN9ASCN5ASCN2BSCN1ASCN1B | |
| SCHEMBL16178222 | 0.78 | SCN9A (1.00) | SCN9ASCN5ASCN2BSCN1ASCN1B | |
| SCHEMBL16239769 | 0.77 | SCN9A (0.67) | SCN9ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593431-B1 | N-SULFONYLBENZAMIDES AS INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | PFIZER LTD (GB) | 2014-11-19 | — | — | EP | disclosed |