SCHEMBL16239657

SCHEMBL16239657

CS(=O)(=O)NC(=O)c1cc(F)c(COc2ccc(F)c(Cl)c2)cc1F

nearest known ligand 0.88

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 20/20 0.88
SCN5A Q14524 1/20 0.88

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL366583 0.93 SCN9A (1.00) SCN9ASCN5A
SCHEMBL16240263 0.91 SCN9A (0.84) SCN9ASCN5A
SCHEMBL16239633 0.91 SCN9A (0.88) SCN9ASCN5A
SCHEMBL16239910 0.90 SCN9A (0.78) SCN9ASCN5A
SCHEMBL16239881 0.89 SCN9A (0.84) SCN9ASCN5A
SCHEMBL16239734 0.89 SCN9A (0.79) SCN9ASCN5A
Diethylamine SCHEMBL14890296 0.89 SCN9A (0.90) SCN9ASCN5A
SCHEMBL10203169 0.89 SCN9A (0.79) SCN9ASCN5A
SCHEMBL15018087 0.88 SCN9A (0.78) SCN9ASCN5A
SCHEMBL16240228 0.88 SCN9A (0.78) SCN9ASCN5A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2593428-B1 N-SULFONYLBENZAMIDES AS INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS PFIZER LTD (GB) 2014-11-19 EP disclosed