SCHEMBL16239692

SCHEMBL16239692

COc1cc(C#N)ccc1OCc1cc(F)c(C(=O)NS(C)(=O)=O)cc1F

nearest known ligand 0.55

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 20/20 0.55
SCN5A Q14524 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16239952 0.91 SCN9A (0.58) SCN9ASCN5A
SCHEMBL16239964 0.88 SCN9A (0.63) SCN9ASCN5A
SCHEMBL364953 0.85 SCN9A (0.63) SCN9ASCN5A
SCHEMBL16239918 0.84 SCN9A (0.62) SCN9ASCN5A
SCHEMBL16239719 0.84 SCN9A (0.62) SCN9ASCN5A
SCHEMBL16319559 0.84 SCN9A (0.53) SCN9ASCN5A
SCHEMBL16239723 0.83 SCN9A (0.59) SCN9ASCN5A
SCHEMBL16239551 0.83 SCN9A (0.67) SCN9ASCN5A
SCHEMBL16240233 0.82 SCN9A (0.65) SCN9ASCN5A
SCHEMBL16239728 0.82 SCN9A (0.57) SCN9ASCN5A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2593428-B1 N-SULFONYLBENZAMIDES AS INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS PFIZER LTD (GB) 2014-11-19 EP disclosed