SCHEMBL16239795

SCHEMBL16239795

CC(C)C(=O)N1CCC(C(=O)N2C[C@@H](c3ccc(Cl)cc3)[C@](C)(CNC(=O)O)C2)CC1

nearest known ligand 0.68

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TACR3 P29371 18/20 0.68
CCR1 P32246 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16239789 0.90 TACR3 (0.66) TACR3
SCHEMBL16239636 0.88 TACR3 (0.55) TACR3
SCHEMBL16239540 0.86 TACR3 (0.69) TACR3
SCHEMBL16239680 0.82 TACR3 (0.70) TACR3
SCHEMBL6837235 0.81 TACR3 (1.00) TACR3
SCHEMBL325826 0.81 TACR3 (1.00) TACR3
SCHEMBL16239814 0.80 TACR3 (0.75) TACR3
SCHEMBL16239796 0.80 TACR3 (0.73) TACR3
SCHEMBL16239672 0.79 TACR3 (0.55) TACR3CCR1
SCHEMBL16239851 0.73 TACR3 (0.70) TACR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2661432-B1 PYRROLIDINE DERIVATIVES AS NK3 ANTAGONISTS HOFFMANN LA ROCHE (CH) 2014-11-19 EP claimed