SCHEMBL16245754

SCHEMBL16245754

C1=CC=C2Nc3ccccc3C=C2C=C1

nearest known ligand 0.42

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.42
MAPT P10636 1/20 0.42
LMNA P02545 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29992917 1.00 GAA (0.42) GAAMAPTLMNASMN1; SMN2
SCHEMBL6306595 0.85 GAA (0.40) GAAMAPTLMNASMN1; SMN2
SCHEMBL17541180 0.75 GAA (0.38) GAAMAPTLMNASMN1; SMN2
SCHEMBL27682260 0.72 GAA (0.36) GAAMAPTLMNASMN1; SMN2
SCHEMBL6010290 0.68 GAA (0.52) GAAMAPTSMN1; SMN2
SCHEMBL5866547 0.67 GAA (0.37) GAAMAPT
SCHEMBL3732226 0.67 GAA (0.50) GAAMAPTLMNASMN1; SMN2
SCHEMBL4651143 0.67 GAA (0.36) GAAMAPT
SCHEMBL3791849 0.67 GAA (0.36) GAAMAPT
SCHEMBL27881138 0.66 GAA (0.40) GAAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019149260-A1 PYRIDAZINOL COMPOUND, DERIVATIVE THEREOF, PREPARATION METHOD THEREFOR, HERBICIDAL COMPOSITION AND USE THEREOF 青岛清原化合物有限公司 2019-08-08 WO disclosed
WO-2019148851-A1 FIVE-MEMBERED RING-SUBSTITUTED PYRIDAZINOL COMPOUND AND DERIVATIVES THEREOF, PREPARATION METHOD, HERBICIDAL COMPOSITION, AND APPLICATION 青岛清原化合物有限公司 2019-08-08 WO disclosed
EP-3039012-A1 HISTONE DEACETYLASE INHIBITORS BASED ON DERIVATIVES OF TRICYCLIC POLYHYDROACRIDINE AND ANALOGS POSSESSING FUSED SATURATED FIVE- AND SEVEN-MEMBERED RINGS QUIMATRYX, S.L (ES) 2016-07-06 EP disclosed
WO-2014180984-A1 HISTONE DEACETYLASE INHIBITORS BASED ON DERIVATIVES OF TRICYCLIC POLYHYDROACRIDINE AND ANALOGS POSSESSING FUSED SATURATED FIVE- AND SEVEN-MEMBERED RINGS IKERCHEM, S.L. (ES) 2014-11-13 WO disclosed