Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 16/20 | 0.58 |
| ▸ | BTK | Q06187 | 1/20 | 0.51 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.50 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.50 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.50 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.47 |
| ▸ | SIK1 | P57059 | 2/20 | 0.47 |
| ▸ | SIK2 | Q9H0K1 | 2/20 | 0.47 |
| ▸ | SIK3 | Q9Y2K2 | 2/20 | 0.47 |
| ▸ | GAK | O14976 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.47 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.47 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.47 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.47 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.47 |
| ▸ | EPHB1 | P54762 | 1/20 | 0.47 |
| ▸ | EPHA4 | P54764 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16246022 | 0.90 | FGFR1 (0.63) | FGFR1FGFR2FGFR4FGFR3PAK1 | |
| SCHEMBL16246288 | 0.88 | FGFR1 (0.58) | FGFR1BTKFGFR2FGFR4FGFR3 | |
| SCHEMBL16246002 | 0.87 | FGFR1 (0.65) | FGFR1BTK | |
| SCHEMBL16245975 | 0.86 | FGFR1 (0.75) | FGFR1BTKFGFR2 | |
| SCHEMBL16246120 | 0.85 | FGFR1 (0.56) | FGFR1FGFR2FGFR4FGFR3PAK1 | |
| SCHEMBL16246089 | 0.85 | FGFR1 (0.78) | FGFR1FGFR4 | |
| SCHEMBL16245966 | 0.83 | FGFR1 (0.62) | FGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL16246142 | 0.81 | FGFR1 (0.73) | FGFR1FGFR4 | |
| SCHEMBL16246412 | 0.81 | FGFR1 (0.66) | FGFR1BTKFGFR4 | |
| SCHEMBL16246319 | 0.79 | FGFR1 (0.79) | FGFR1FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2994470-B1 | PYRIDO[2,3-D]PYRIMIDINE DERIVATIVES AS FIBROBLAST GROWTH FACTOR INHIBITORS | PRINCIPIA BIOPHARMA INC (US) | 2018-04-18 | — | — | EP | disclosed |
| US-9630963-B2 | Quinolone derivatives as fibroblast growth factor inhibitors | PRINCIPIA BIOPHARMA, INC. (US) | 2017-04-25 | — | — | US | disclosed |
| US-20160130268-A1 | QUINOLONE DERIVATIVES AS FIBROBLAST GROWTH FACTOR INHIBITORS | PRINCIPIA BIOPHARMA INC. | 2016-05-12 | — | — | US | disclosed |
| EP-2994470-A1 | QUINOLONE DERIVATIVES AS FIBROBLAST GROWTH FACTOR INHIBITORS | Principia Biopharma Inc. (US) | 2016-03-16 | — | — | EP | disclosed |
| WO-2014182829-A1 | QUINOLONE DERIVATIVES AS FIBROBLAST GROWTH FACTOR INHIBITORS | PRINCIPIA BIOPHARMA INC. (US) | 2014-11-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160130268-A1 | QUINOLONE DERIVATIVES AS FIBROBLAST GROWTH FACTOR INHIBITORS | FGFR1, FGFR3, FGFR2 | FGFR1 1/4885BTK 374/4885FGFR2 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.