Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | SNCA | P37840 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.40 |
| ▸ | RHOA | P61586 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TPMT | P51580 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7196703 | 1.00 | CYP3A4 (0.52) | CYP3A4SNCAALDH1A1TSHRHSD17B10 | |
| SCHEMBL254063 | 0.92 | CYP3A4 (0.59) | CYP3A4SNCAALDH1A1TSHRHSD17B10 | |
| SCHEMBL4657758 | 0.86 | NPC1 (0.48) | CYP3A4ALDH1A1MEN1KMT2AGAA | |
| SCHEMBL2392472 | 0.86 | CYP3A4 (0.54) | CYP3A4SNCAALDH1A1TSHRHSD17B10 | |
| SCHEMBL175787 | 0.85 | SNCA (0.59) | CYP3A4SNCAALDH1A1TSHRHSD17B10 | |
| SCHEMBL7139650 | 0.85 | CA12 (0.53) | CYP3A4SNCAALDH1A1TSHRHSD17B10 | |
| Phosphine SCHEMBL10982972 | 0.84 | CYP3A4 (0.53) | CYP3A4SNCAALDH1A1TSHRHSD17B10 | |
| Isophthalic Acid SCHEMBL28712224 | 0.84 | CYP3A4 (0.53) | CYP3A4SNCAALDH1A1TSHRHSD17B10 | |
| SCHEMBL5889080 | 0.84 | CYP2C9 (0.64) | CYP3A4SNCAALDH1A1TSHRHSD17B10 | |
| SCHEMBL31666355 | 0.83 | CYP3A4 (0.44) | CYP3A4SNCAALDH1A1TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2999483-B1 | CHEMICAL SYNTHESIS AND SCREENING OF BICYCLIC PEPTIDE LIBRARIES | OHIO STATE INNOVATION FOUNDATION (US) | 2018-10-31 | — | — | EP | disclosed |
| US-20180030094-A1 | CHEMICAL SYNTHESIS AND SCREENING OF BICYCLIC PEPTIDE LIBRARIES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-02-01 | — | — | US | disclosed |
| US-20180030094-A1 | CHEMICAL SYNTHESIS AND SCREENING OF BICYCLIC PEPTIDE LIBRARIES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-02-01 | — | — | US | disclosed |
| US-20180030094-A1 | CHEMICAL SYNTHESIS AND SCREENING OF BICYCLIC PEPTIDE LIBRARIES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-02-01 | — | — | US | disclosed |
| US-9868767-B2 | Chemical synthesis and screening of bicyclic peptide libraries | OHIO STATE INNOVATION FOUNDATION (US) | 2018-01-16 | — | — | US | disclosed |
| US-9868767-B2 | Chemical synthesis and screening of bicyclic peptide libraries | OHIO STATE INNOVATION FOUNDATION (US) | 2018-01-16 | — | — | US | disclosed |
| US-9868767-B2 | Chemical synthesis and screening of bicyclic peptide libraries | OHIO STATE INNOVATION FOUNDATION (US) | 2018-01-16 | — | — | US | disclosed |
| US-20160115202-A1 | CHEMICAL SYNTHESIS AND SCREENING OF BICYCLIC PEPTIDE LIBRARIES | OHIO STATE INNOVATION FOUNDATION | 2016-04-28 | — | — | US | disclosed |
| US-20160115202-A1 | CHEMICAL SYNTHESIS AND SCREENING OF BICYCLIC PEPTIDE LIBRARIES | OHIO STATE INNOVATION FOUNDATION | 2016-04-28 | — | — | US | disclosed |
| US-20160115202-A1 | CHEMICAL SYNTHESIS AND SCREENING OF BICYCLIC PEPTIDE LIBRARIES | OHIO STATE INNOVATION FOUNDATION | 2016-04-28 | — | — | US | disclosed |
| EP-2999483-A2 | CHEMICAL SYNTHESIS AND SCREENING OF BICYCLIC PEPTIDE LIBRARIES | Ohio State Innovation Foundation (US) | 2016-03-30 | — | — | EP | disclosed |
| WO-2014190257-A2 | CHEMICAL SYNTHESIS AND SCREENING OF BICYCLIC PEPTIDE LIBRARIES | OHIO STATE INNOVATION FOUNDATION (US) | 2014-11-27 | — | — | WO | disclosed |
| WO-2014190257-A2 | CHEMICAL SYNTHESIS AND SCREENING OF BICYCLIC PEPTIDE LIBRARIES | OHIO STATE INNOVATION FOUNDATION (US) | 2014-11-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180030094-A1 | CHEMICAL SYNTHESIS AND SCREENING OF BICYCLIC PEPTIDE LIBRARIES | BAD, VIP, SSB | CYP3A4 4338/4885SNCA 3575/4885ALDH1A1 4633/4885 |
| US-20160115202-A1 | CHEMICAL SYNTHESIS AND SCREENING OF BICYCLIC PEPTIDE LIBRARIES | BAD, VIP, SSB | CYP3A4 4338/4885SNCA 3575/4885ALDH1A1 4633/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.