SCHEMBL16246952

SCHEMBL16246952

FC(F)(F)c1ccc(-c2nc3ccc(-c4ccccc4)cn3c2CN2CCOCC2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ SLC2A1 P11166 18/20 1.00
▸ SMN1; SMN2 Q16637 1/20 0.67
▸ SLC2A3 P11169 1/20 0.65
▸ SLC2A4 P14672 1/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17718873 0.91 SLC2A1 (1.00) SLC2A1SMN1; SMN2SLC2A3SLC2A4
SCHEMBL17718852 0.88 SLC2A1 (1.00) SLC2A1SMN1; SMN2SLC2A3SLC2A4
SCHEMBL17718848 0.88 SLC2A1 (0.89) SLC2A1SMN1; SMN2SLC2A3SLC2A4
SCHEMBL16246716 0.86 SLC2A1 (1.00) SLC2A1SLC2A3SLC2A4
SCHEMBL17718919 0.86 SLC2A1 (1.00) SLC2A1SMN1; SMN2SLC2A3SLC2A4
SCHEMBL17718907 0.84 SLC2A1 (1.00) SLC2A1SLC2A3SLC2A4
SCHEMBL17719146 0.84 SLC2A1 (0.85) SLC2A1SMN1; SMN2SLC2A3SLC2A4
SCHEMBL17718876 0.83 SLC2A1 (0.83) SLC2A1SMN1; SMN2SLC2A3SLC2A4
SCHEMBL17718875 0.83 SLC2A1 (1.00) SLC2A1SMN1; SMN2
SCHEMBL17718904 0.82 SLC2A1 (1.00) SLC2A1SMN1; SMN2SLC2A3SLC2A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160120863-A1 SLC2A TRANSPORTER INHIBITORS IOMET PHARMA LTD. (GB) 2016-05-05 — — US disclosed
US-20160120863-A1 SLC2A TRANSPORTER INHIBITORS IOMET PHARMA LTD. (GB) 2016-05-05 — — US disclosed
US-20160120863-A1 SLC2A TRANSPORTER INHIBITORS IOMET PHARMA LTD. (GB) 2016-05-05 — — US disclosed
EP-3004088-A1 SLC2A TRANSPORTER INHIBITORS Iomet Pharma Ltd. (GB) 2016-04-13 — — EP disclosed
WO-2014187922-A1 SLC2A TRANSPORTER INHIBITORS IOMET PHARMA LTD. (GB) 2014-11-27 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160120863-A1 SLC2A TRANSPORTER INHIBITORS SLCO1A2, SLCO2B1, SLCO2A1 SLC2A1 6/4885SMN1; SMN2 3724/4885SLC2A3 13/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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