Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 20/20 | 1.00 |
| ▸ | RPS6KB1 | P23443 | 19/20 | 1.00 |
| ▸ | AKT2 | P31751 | 3/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 3/20 | 1.00 |
| ▸ | AKT3 | Q9Y243 | 3/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14791928 | 0.98 | RPS6KB1 (1.00) | AKT1RPS6KB1AKT2KCNH2AKT3 | |
| SCHEMBL14792293 | 0.98 | RPS6KB1 (1.00) | AKT1RPS6KB1AKT2KCNH2AKT3 | |
| SCHEMBL14792311 | 0.93 | RPS6KB1 (1.00) | AKT1RPS6KB1AKT2KCNH2AKT3 | |
| SCHEMBL14782403 | 0.93 | AKT1 (1.00) | AKT1RPS6KB1AKT2KCNH2AKT3 | |
| SCHEMBL16247287 | 0.93 | RPS6KB1 (1.00) | AKT1RPS6KB1AKT2KCNH2AKT3 | |
| SCHEMBL14782538 | 0.92 | RPS6KB1 (1.00) | AKT1RPS6KB1AKT2KCNH2AKT3 | |
| SCHEMBL14786538 | 0.92 | RPS6KB1 (1.00) | AKT1RPS6KB1AKT2KCNH2AKT3 | |
| SCHEMBL16247296 | 0.92 | RPS6KB1 (1.00) | AKT1RPS6KB1AKT2KCNH2AKT3 | |
| SCHEMBL16247297 | 0.91 | AKT1 (1.00) | AKT1RPS6KB1AKT2KCNH2AKT3 | |
| SCHEMBL16987133 | 0.90 | RPS6KB1 (0.97) | AKT1RPS6KB1AKT2KCNH2AKT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970201-B1 | 6-[4-(1H-IMIDAZOL-2-YL)PIPERIDIN-1-YL]PYRIMIDIN-4-AMINE DERIVATIVES AS MODULATORS OF KINASE ACTIVITY | MERCK PATENT GMBH (DE) | 2019-06-19 | — | — | EP | disclosed |
| EP-2755965-B1 | NOVEL IMIDAZOLE AMINES AS MODULATORS OF KINASE ACTIVITY | MERCK PATENT GMBH (DE) | 2017-07-26 | — | — | EP | disclosed |
| US-20160000785-A1 | Novel Imidazole Amines as Modulators of Kinase Activity | MERCK PATENT GMBH (DE) | 2016-01-07 | — | — | US | disclosed |
| US-20160000785-A1 | Novel Imidazole Amines as Modulators of Kinase Activity | MERCK PATENT GMBH (DE) | 2016-01-07 | — | — | US | disclosed |
| US-9145392-B2 | Imidazole amines as modulators of kinase activity | MERCK PATENT GMBH (DE) | 2015-09-29 | — | — | US | disclosed |
| US-9145392-B2 | Imidazole amines as modulators of kinase activity | MERCK PATENT GMBH (DE) | 2015-09-29 | — | — | US | disclosed |
| US-20140343029-A1 | Novel Imidazole Amines as Modulators of Kinase Activity | MERCK PATENT GMBH (DE) | 2014-11-20 | — | — | US | disclosed |
| US-20140343029-A1 | Novel Imidazole Amines as Modulators of Kinase Activity | MERCK PATENT GMBH (DE) | 2014-11-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160000785-A1 | Novel Imidazole Amines as Modulators of Kinase Activity | MAP3K11, MAP3K20, MAP3K19 | AKT1 291/4885RPS6KB1 271/4885AKT2 383/4885 |
| US-20140343029-A1 | Novel Imidazole Amines as Modulators of Kinase Activity | MAP3K11, MAP3K20, MAP3K19 | AKT1 291/4885RPS6KB1 271/4885AKT2 383/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.