Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S100A9 | P06702 | 10/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.37 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | VEGFA | P15692 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16235153 | 0.88 | S100A9 (0.64) | S100A9KDM4EERCC1ERCC4 | |
| SCHEMBL16235324 | 0.86 | S100A9 (0.63) | S100A9KDM4EERCC1ERCC4HTT | |
| SCHEMBL16235281 | 0.85 | S100A9 (0.64) | S100A9KDM4EMEN1KMT2AERCC1 | |
| SCHEMBL16235928 | 0.81 | S100A9 (0.78) | S100A9KDM4E | |
| SCHEMBL16235507 | 0.80 | S100A9 (0.64) | S100A9KDM4EMEN1KMT2A | |
| SCHEMBL16235155 | 0.78 | S100A9 (0.62) | S100A9KDM4EMEN1KMT2A | |
| SCHEMBL16235836 | 0.78 | S100A9 (0.76) | S100A9KDM4E | |
| SCHEMBL16235799 | 0.78 | S100A9 (0.64) | S100A9KDM4EERCC1ERCC4 | |
| SCHEMBL16235632 | 0.77 | S100A9 (0.76) | S100A9KDM4ECA1CA2 | |
| SCHEMBL16235446 | 0.77 | S100A9 (1.00) | S100A9KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925743-B1 | N-(HETEROARYL)-SULFONAMIDE DERIVATIVES USEFUL AS S100-INHIBITORS | ACTIVE BIOTECH AB (SE) | 2016-02-03 | — | — | EP | disclosed |
| WO-2014184234-A1 | N-(HETEROARYL)-SULFONAMIDE DERIVATIVES USEFUL AS S100-INHIBITORS | ACTIVE BIOTECH AB (SE) | 2014-11-20 | — | — | WO | disclosed |