Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 1/20 | 0.63 |
| ▸ | JAK2 | O60674 | 10/20 | 0.55 |
| ▸ | FYN | P06241 | 6/20 | 0.53 |
| ▸ | JAK3 | P52333 | 6/20 | 0.53 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.53 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.52 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.49 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | CDK9 | P50750 | 1/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.49 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.49 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3213779 | 0.93 | JAK2 (0.65) | JAK1JAK2FYNJAK3PTK2 | |
| SCHEMBL2145631 | 0.91 | JAK1 (0.65) | JAK1JAK2FYNJAK3PTK2 | |
| SCHEMBL3215609 | 0.91 | JAK1 (0.60) | JAK1JAK2FYNJAK3PTK2 | |
| SCHEMBL3202389 | 0.90 | JAK1 (0.59) | JAK1JAK2FYNJAK3PTK2 | |
| SCHEMBL16248928 | 0.86 | JAK2 (0.58) | JAK1JAK2JAK3PTK2 | |
| SCHEMBL16248911 | 0.86 | JAK2 (0.56) | JAK1JAK2JAK3PTK2 | |
| SCHEMBL3219907 | 0.84 | FYN (0.60) | JAK1JAK2FYNJAK3PTK2 | |
| SCHEMBL3214292 | 0.84 | JAK1 (0.53) | JAK1JAK2FYNJAK3PTK2 | |
| SCHEMBL16248910 | 0.84 | JAK2 (0.68) | JAK1JAK2FYNJAK3PTK2 | |
| SCHEMBL16248942 | 0.83 | JAK2 (0.60) | JAK1JAK2FYNJAK3PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8889673-B2 | Triazolopyridine JAK inhibitor compounds and methods | GENENTECH, INC. (US) | 2014-11-18 | — | — | US | disclosed |