Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 20/20 | 0.62 |
| ▸ | JAK3 | P52333 | 18/20 | 0.62 |
| ▸ | PTK2 | Q05397 | 16/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3212553 | 0.92 | JAK2 (0.61) | JAK2JAK3PTK2 | |
| SCHEMBL3194593 | 0.91 | JAK2 (0.59) | JAK2JAK3PTK2 | |
| SCHEMBL3213596 | 0.88 | JAK2 (0.67) | JAK2JAK3PTK2 | |
| SCHEMBL16248922 | 0.87 | JAK2 (0.54) | JAK2JAK3PTK2 | |
| SCHEMBL3204260 | 0.87 | JAK2 (0.59) | JAK2JAK3PTK2 | |
| SCHEMBL3197047 | 0.87 | JAK2 (0.64) | JAK2JAK3PTK2 | |
| SCHEMBL13579124 | 0.86 | JAK2 (0.52) | JAK2JAK3PTK2 | |
| SCHEMBL3205739 | 0.86 | JAK2 (0.73) | JAK2JAK3PTK2 | |
| SCHEMBL3208965 | 0.86 | JAK2 (0.69) | JAK2JAK3PTK2 | |
| SCHEMBL3208983 | 0.85 | JAK2 (0.71) | JAK2JAK3PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8889673-B2 | Triazolopyridine JAK inhibitor compounds and methods | GENENTECH, INC. (US) | 2014-11-18 | — | — | US | disclosed |