Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA1 | P02708 | 1/20 | 0.33 |
| ▸ | CHRNG | P07510 | 1/20 | 0.33 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | CHRND | Q07001 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16253348 | 0.84 | CHRNA1 (0.34) | CHRNA1CHRNGCHRNB1CHRNB2CHRNB4 | |
| SCHEMBL12257649 | 0.79 | CHRNA1 (0.38) | CHRNA1CHRNGCHRNB1CHRNB2CHRNB4 | |
| SCHEMBL20349521 | 0.76 | CHRNA1 (0.36) | CHRNA1CHRNGCHRNB1CHRNB2CHRNB4 | |
| SCHEMBL12257641 | 0.74 | CHRNA1 (0.34) | CHRNA1CHRNGCHRNB1CHRNB2CHRNB4 | |
| SCHEMBL18969278 | 0.72 | CHRNA1 (0.35) | CHRNA1CHRNGCHRNB1CHRNB2CHRNB4 | |
| SCHEMBL9963293 | 0.71 | CYP2D6 (0.36) | CHRNA1CHRNGCHRNB1CHRNB2CHRNB4 | |
| SCHEMBL16249370 | 0.69 | — | — | |
| SCHEMBL16249369 | 0.69 | — | — | |
| SCHEMBL21214499 | 0.69 | CHRNA1 (0.31) | CHRNA1CHRNGCHRNB1CHRNB2CHRNB4 | |
| SCHEMBL18969266 | 0.69 | SMN1; SMN2 (0.32) | CHRNA1CHRNGCHRNB1CHRNB2CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8889704-B2 | Triazolopyridine compounds as PIM kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2014-11-18 | — | — | US | disclosed |