Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHOA | P61586 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.33 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 3/20 | 0.32 |
| ▸ | KDR | P35968 | 3/20 | 0.32 |
| ▸ | TEK | Q02763 | 3/20 | 0.32 |
| ▸ | WNT1 | P04628 | 1/20 | 0.31 |
| ▸ | CLK2 | P49760 | 1/20 | 0.31 |
| ▸ | IDH2 | P48735 | 3/20 | 0.31 |
| ▸ | CCR3 | P51677 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16775800 | 0.94 | RHOA (0.38) | RHOAMEN1KMT2AALDH1A1DYRK1A | |
| SCHEMBL16238473 | 0.94 | RHOA (0.38) | RHOAMEN1KMT2AALDH1A1DYRK1A | |
| SCHEMBL16238714 | 0.91 | RHOA (0.43) | RHOAMEN1KMT2AALDH1A1DYRK1A | |
| SCHEMBL17618881 | 0.91 | RHOA (0.40) | RHOACA2CA9LCKKDR | |
| SCHEMBL16785596 | 0.91 | RHOA (0.37) | RHOAMEN1KMT2AALDH1A1DYRK1A | |
| SCHEMBL19706159 | 0.90 | RHOA (0.36) | RHOAMEN1KMT2AALDH1A1DYRK1A | |
| SCHEMBL16249983 | 0.88 | RHOA (0.48) | RHOAMEN1KMT2AALDH1A1CA2 | |
| SCHEMBL19865069 | 0.88 | RHOA (0.48) | RHOAMEN1KMT2AALDH1A1CA2 | |
| SCHEMBL16250011 | 0.88 | RHOA (0.48) | RHOAMEN1KMT2AALDH1A1CA2 | |
| SCHEMBL17624671 | 0.88 | RHOA (0.38) | RHOADYRK1AGSK3BCA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014186313-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2014-11-20 | — | — | WO | disclosed |