Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 14/20 | 0.63 |
| ▸ | JAK1 | P23458 | 5/20 | 0.61 |
| ▸ | JAK3 | P52333 | 7/20 | 0.55 |
| ▸ | PTK2 | Q05397 | 6/20 | 0.55 |
| ▸ | TYK2 | P29597 | 1/20 | 0.47 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7964178 | 0.88 | JAK2 (0.81) | JAK2JAK1JAK3PTK2TYK2 | |
| SCHEMBL16250512 | 0.88 | JAK2 (0.62) | JAK2JAK1JAK3PTK2TYK2 | |
| SCHEMBL16364893 | 0.87 | JAK2 (0.58) | JAK2JAK1JAK3PTK2 | |
| SCHEMBL3215657 | 0.86 | JAK2 (0.63) | JAK2JAK1JAK3PTK2 | |
| SCHEMBL13073401 | 0.85 | JAK2 (0.76) | JAK2JAK1JAK3PTK2TYK2 | |
| SCHEMBL2146398 | 0.85 | JAK2 (0.75) | JAK2JAK1JAK3PTK2 | |
| SCHEMBL3192870 | 0.84 | JAK2 (0.63) | JAK2JAK1JAK3PTK2 | |
| SCHEMBL3205653 | 0.84 | JAK2 (0.61) | JAK2JAK1JAK3PTK2 | |
| SCHEMBL16250537 | 0.82 | JAK2 (0.51) | JAK2JAK1JAK3PTK2TYK2 | |
| SCHEMBL3208718 | 0.81 | JAK2 (0.82) | JAK2JAK1JAK3PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8889673-B2 | Triazolopyridine JAK inhibitor compounds and methods | GENENTECH, INC. (US) | 2014-11-18 | — | — | US | disclosed |