Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 15/20 | 0.36 |
| ▸ | JAK2 | O60674 | 3/20 | 0.36 |
| ▸ | JAK1 | P23458 | 3/20 | 0.36 |
| ▸ | TTK | P33981 | 3/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | TXK | P42681 | 1/20 | 0.36 |
| ▸ | BLK | P51451 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | ITK | Q08881 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10206650 | 0.92 | LRRK2 (0.36) | JAK3JAK2JAK1TTKEGFR | |
| SCHEMBL10205075 | 0.88 | STK17A (0.40) | JAK3JAK2JAK1EGFRFLT3 | |
| SCHEMBL10207052 | 0.88 | JAK3 (0.35) | JAK3JAK2JAK1TTKEGFR | |
| SCHEMBL10205875 | 0.84 | LRRK2 (0.39) | JAK3JAK2EGFRLRRK2 | |
| SCHEMBL10206623 | 0.82 | JAK3 (0.37) | JAK3JAK2JAK1TTKEGFR | |
| SCHEMBL10205539 | 0.81 | ALK (0.42) | EGFRLRRK2 | |
| SCHEMBL10205081 | 0.80 | FLT3 (0.42) | JAK3JAK2EGFRFLT3LRRK2 | |
| SCHEMBL10206652 | 0.80 | LRRK2 (0.38) | JAK3JAK2EGFRLRRK2 | |
| SCHEMBL10206638 | 0.79 | ALK (0.42) | JAK3FLT3 | |
| SCHEMBL10205191 | 0.79 | EGFR (0.41) | JAK3JAK2JAK1TTKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655358-B1 | OXINDOLOPYRIMIDINE AS IGF1R RECEPTOR INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2014-11-19 | — | — | EP | disclosed |