Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 5/20 | 0.39 |
| ▸ | STAT6 | P42226 | 2/20 | 0.39 |
| ▸ | JAK3 | P52333 | 4/20 | 0.37 |
| ▸ | EGFR | P00533 | 3/20 | 0.37 |
| ▸ | ITK | Q08881 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 4/20 | 0.36 |
| ▸ | JUN | P05412 | 2/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | TYK2 | P29597 | 2/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10205194 | 0.93 | JAK3 (0.42) | PTK2STAT6JAK3EGFRJUN | |
| SCHEMBL10205925 | 0.93 | IGF1R (0.39) | PTK2STAT6JUNMAPK8MAPK9 | |
| SCHEMBL10205899 | 0.86 | EGFR (0.39) | PTK2JAK3EGFRITKJUN | |
| SCHEMBL10205930 | 0.86 | PTK2 (0.35) | PTK2JAK3EGFRJUNMAPK8 | |
| SCHEMBL10206621 | 0.85 | JAK3 (0.43) | PTK2STAT6JAK3EGFRJAK2 | |
| SCHEMBL10205202 | 0.82 | JAK3 (0.40) | PTK2STAT6JAK3EGFRJAK2 | |
| SCHEMBL10207078 | 0.82 | STAT6 (0.40) | PTK2STAT6SYKTYK2NTRK1 | |
| SCHEMBL10205197 | 0.80 | ALK (0.43) | JAK3CDK2JAK2TYK2NTRK1 | |
| SCHEMBL10205927 | 0.80 | TNK2 (0.39) | PTK2STAT6JAK3BRD4SYK | |
| SCHEMBL10206632 | 0.79 | PTK2 (0.41) | PTK2JAK3JAK2TYK2NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655358-B1 | OXINDOLOPYRIMIDINE AS IGF1R RECEPTOR INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2014-11-19 | — | — | EP | disclosed |