Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.48 |
| ▸ | MET | P08581 | 1/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | INSR | P06213 | 1/20 | 0.44 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.44 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.41 |
| ▸ | FLT4 | P35916 | 3/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10206156 | 0.92 | ALK (0.48) | EGFRMETALKKCNH2INSR | |
| SCHEMBL10205156 | 0.92 | EGFR (0.47) | EGFRMETALKKCNH2INSR | |
| SCHEMBL16255608 | 0.91 | EGFR (0.47) | EGFRALKINSRTNK2NTRK1 | |
| SCHEMBL10206144 | 0.90 | EGFR (0.59) | EGFRMETALKKCNH2INSR | |
| SCHEMBL14331595 | 0.87 | STK17A (0.58) | EGFRMETSTK17ATNK2NTRK1 | |
| SCHEMBL10205066 | 0.87 | PTK2 (0.51) | EGFRMETALKKCNH2INSR | |
| SCHEMBL10205832 | 0.87 | ALK (0.53) | EGFRMETALKKCNH2INSR | |
| SCHEMBL10205064 | 0.86 | ALK (0.42) | EGFRMETALKKCNH2INSR | |
| SCHEMBL10205062 | 0.85 | ALK (0.49) | EGFRMETALKKCNH2INSR | |
| SCHEMBL10205075 | 0.84 | STK17A (0.40) | EGFRMETALKKCNH2INSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655358-B1 | OXINDOLOPYRIMIDINE AS IGF1R RECEPTOR INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2014-11-19 | — | — | EP | disclosed |