Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 8/20 | 0.58 |
| ▸ | PRKCD | Q05655 | 6/20 | 0.58 |
| ▸ | PIM1 | P11309 | 8/20 | 0.53 |
| ▸ | ACVR1 | Q04771 | 4/20 | 0.48 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.42 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9881957 | 0.86 | PRKCQ (0.68) | PRKCQPRKCDPIM1PIM3PIM2 | |
| SCHEMBL9882013 | 0.86 | PRKCQ (0.68) | PRKCQPRKCDPIM1PIM3PIM2 | |
| SCHEMBL12433139 | 0.84 | PIM1 (0.55) | PRKCQPRKCDPIM1PIM3PIM2 | |
| SCHEMBL14725582 | 0.83 | PRKCQ (0.53) | PRKCQPRKCDPIM1 | |
| SCHEMBL9881987 | 0.79 | PIM1 (0.58) | PRKCQPRKCDPIM1ACVR1PIM3 | |
| SCHEMBL9882010 | 0.75 | PRKCQ (0.69) | PRKCQPRKCDPIM1PIM3PIM2 | |
| SCHEMBL9882019 | 0.74 | PRKCQ (0.53) | PRKCQPRKCDPIM1 | |
| SCHEMBL9882005 | 0.74 | PRKCQ (0.70) | PRKCQPRKCDPIM1PIM3PIM2 | |
| SCHEMBL9881985 | 0.73 | PRKCQ (0.52) | PRKCQPRKCDPIM1PIM3PIM2 | |
| SCHEMBL9882088 | 0.73 | PRKCQ (0.52) | PRKCQPRKCDPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8895740-B2 | Pyrazolopyrazine kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-11-25 | — | — | US | disclosed |