Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A3 | Q92570 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KDM5A | P29375 | 2/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4757065 | 0.83 | NR4A3 (0.58) | NR4A3KDM4EALDH1A1TDP1L3MBTL1 | |
| SCHEMBL27843124 | 0.79 | NR4A3 (0.46) | NR4A3KDM4EALDH1A1TDP1L3MBTL1 | |
| SCHEMBL21960891 | 0.79 | NR4A3 (0.43) | NR4A3KDM4EALDH1A1TDP1L3MBTL1 | |
| SCHEMBL31053372 | 0.79 | NR4A3 (0.43) | NR4A3KDM4EALDH1A1TDP1L3MBTL1 | |
| SCHEMBL30322820 | 0.78 | NR4A3 (0.40) | NR4A3KDM4EALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL29224393 | 0.78 | NR4A3 (0.40) | NR4A3KDM4EALDH1A1TDP1L3MBTL1 | |
| SCHEMBL22534352 | 0.76 | NR4A3 (0.51) | NR4A3KDM4EALDH1A1GAAHSD17B10 | |
| SCHEMBL31053389 | 0.76 | NR4A3 (0.41) | NR4A3KDM4EALDH1A1TDP1L3MBTL1 | |
| SCHEMBL14973140 | 0.75 | SMN1; SMN2 (0.42) | NR4A3KDM4EALDH1A1SMN1; SMN2KDM5A | |
| SCHEMBL15771413 | 0.75 | KDM4E (0.40) | NR4A3KDM4EALDH1A1TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8895583-B2 | Soluble guanylate cyclase activators | MERCK SHARP & DOHME CORP. (US) | 2014-11-25 | — | — | US | disclosed |