Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 18/20 | 0.54 |
| ▸ | KIT | P10721 | 3/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1868772 | 0.79 | CSF1R (0.60) | CSF1RKITCYP2C19CYP3A4CYP2C9 | |
| SCHEMBL14117099 | 0.78 | CSF1R (0.54) | CSF1RKITCYP2C19CYP3A4 | |
| SCHEMBL12667930 | 0.78 | CSF1R (0.58) | CSF1RKITCYP2C19CYP3A4CYP2C9 | |
| SCHEMBL4179189 | 0.74 | CSF1R (0.45) | CSF1RKITCYP2C19CYP3A4CYP2C9 | |
| SCHEMBL1858489 | 0.74 | KIT (0.50) | CSF1RKITCYP2C19CYP3A4 | |
| SCHEMBL4179194 | 0.73 | CSF1R (0.43) | CSF1RKITCYP2C19CYP3A4 | |
| SCHEMBL12422506 | 0.71 | CSF1R (0.60) | CSF1RKITCYP2C19CYP3A4CYP2C9 | |
| SCHEMBL14117386 | 0.71 | CSF1R (0.56) | CSF1RKITCYP2C19CYP3A4 | |
| SCHEMBL12408087 | 0.70 | CSF1R (0.72) | CSF1RKITCYP2C19CYP3A4CYP2C9 | |
| SCHEMBL1858079 | 0.69 | CSF1R (0.57) | CSF1RKITCYP2C19CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8895584-B2 | Inhibitors of c-fms kinase | JANSSEN PHARMACEUTICA NV (BE) | 2014-11-25 | — | — | US | disclosed |