Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 10/20 | 0.69 |
| ▸ | MAP3K7 | O43318 | 7/20 | 0.57 |
| ▸ | MAP2K1 | Q02750 | 6/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.56 |
| ▸ | FLT3 | P36888 | 1/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.52 |
| ▸ | SRC | P12931 | 3/20 | 0.52 |
| ▸ | CTSC | P53634 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | BLK | P51451 | 1/20 | 0.49 |
| ▸ | BMX | P51813 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16207032 | 0.90 | EGFR (0.85) | EGFRMAP3K7MAP2K1MAPK1FLT3 | |
| SCHEMBL16207000 | 0.82 | EGFR (0.87) | EGFRMAP3K7MAP2K1MAPK1FLT3 | |
| SCHEMBL16195490 | 0.81 | EGFR (1.00) | EGFRMAP3K7MAP2K1MAPK1FLT3 | |
| SCHEMBL15134667 | 0.81 | EGFR (0.85) | EGFRMAP3K7MAP2K1MAPK1FLT3 | |
| SCHEMBL18251088 | 0.81 | EGFR (0.71) | EGFRCTSCJAK2BLKBMX | |
| SCHEMBL16207131 | 0.80 | EGFR (0.84) | EGFRMAP3K7MAP2K1MAPK1FLT3 | |
| SCHEMBL15134639 | 0.79 | EGFR (0.70) | EGFRFLT3 | |
| SCHEMBL16207126 | 0.79 | EGFR (0.76) | EGFRMAP3K7MAP2K1MAPK1FLT3 | |
| SCHEMBL15134771 | 0.77 | EGFR (0.82) | EGFRFLT3CTSCJAK2BLK | |
| SCHEMBL16258194 | 0.77 | EGFR (0.49) | EGFRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2805940-A1 | PYRAZINE CARBOXAMIDE COMPOUND | Astellas Pharma Inc. (JP) | 2014-11-26 | — | — | EP | disclosed |