SCHEMBL16258455

CC(C)c1nc2c(c(C3=CCC(F)(F)CC3)c1[C@H](C)c1ccc(C(F)(F)F)cn1)C(O[Si](C)(C)C(C)(C)C)CC(C)(C)C2

nearest known ligand 0.40

Predicted protein targets (top 1)

	gene	UniProt	supporting neighbours	confidence
▸	CETP	P11597	20/20	0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL661668	0.93	CETP (0.40)	CETP
SCHEMBL661412	0.93	CETP (0.40)	CETP
SCHEMBL661411	0.93	CETP (0.40)	CETP
SCHEMBL661413	0.93	CETP (0.40)	CETP
SCHEMBL661667	0.93	CETP (0.40)	CETP
SCHEMBL661669	0.93	CETP (0.40)	CETP
SCHEMBL662431	0.83	CETP (0.42)	CETP
SCHEMBL662429	0.83	CETP (0.42)	CETP
SCHEMBL16360012	0.83	CETP (0.42)	CETP
SCHEMBL664045	0.82	CETP (0.40)	CETP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-2536733-B1	TRICYCLIC PYRIDINE DERIVATIVES, MEDICAMENTS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PREPARATION	BOEHRINGER INGELHEIM INT (DE)	2014-11-26	—	—	EP	disclosed