Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR4 | P51679 | 9/20 | 0.67 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.43 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | INPPL1 | O15357 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16242150 | 0.85 | CCR4 (0.61) | CCR4HTR2AACHEHTR3AHRH4 | |
| SCHEMBL16242019 | 0.83 | CCR4 (0.65) | CCR4HTR3AHRH4 | |
| SCHEMBL16242020 | 0.83 | CCR4 (0.70) | CCR4KDM4E | |
| SCHEMBL16241955 | 0.83 | CCR4 (0.70) | CCR4 | |
| SCHEMBL5417240 | 0.80 | CCR4 (1.00) | CCR4 | |
| SCHEMBL5417235 | 0.80 | CCR4 (1.00) | CCR4 | |
| SCHEMBL16678823 | 0.80 | CCR4 (0.79) | CCR4 | |
| SCHEMBL16242148 | 0.80 | CCR4 (0.81) | CCR4 | |
| SCHEMBL16242149 | 0.80 | CCR4 (0.81) | CCR4 | |
| SCHEMBL5408559 | 0.80 | CCR4 (0.57) | CCR4LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2805947-B1 | PIPERAZINYL PYRIMIDINE DERIVATIVES, PREPARATION METHOD AND USE THEREOF | INST PHARMACOLOGY & TOXICOLOGY ACAD MILITARY MEDICAL SCIENCES PLA CHINA (CN) | 2017-02-22 | — | — | EP | disclosed |
| US-9493453-B2 | Piperazinyl pyrimidine derivatives, preparation method and use thereof | The Institute of Pharmacology and Toxicology Academy of Military Medical Science P.L.A. China (CN) | 2016-11-15 | — | — | US | disclosed |
| US-9493453-B2 | Piperazinyl pyrimidine derivatives, preparation method and use thereof | The Institute of Pharmacology and Toxicology Academy of Military Medical Science P.L.A. China (CN) | 2016-11-15 | — | — | US | disclosed |
| US-20150126500-A1 | PIPERAZINYL PYRIMIDINE DERIVATIVES, PREPARATION METHOD AND USE THEREOF | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2015-05-07 | — | — | US | disclosed |
| US-20150126500-A1 | PIPERAZINYL PYRIMIDINE DERIVATIVES, PREPARATION METHOD AND USE THEREOF | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2015-05-07 | — | — | US | disclosed |
| EP-2805947-A1 | PIPERAZINYL PYRIMIDINE DERIVATIVES, PREPARATION METHOD AND USE THEREOF | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China (CN) | 2014-11-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150126500-A1 | PIPERAZINYL PYRIMIDINE DERIVATIVES, PREPARATION METHOD AND USE THEREOF | CCR4, CCR1, CCR3 | CCR4 1/4885HTR2A 2637/4885CSNK1D 2190/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.