Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 4/20 | 0.42 |
| ▸ | BRD4 | O60885 | 14/20 | 0.41 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.40 |
| ▸ | BRD2 | P25440 | 2/20 | 0.40 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16259130 | 0.81 | ERN1 (0.42) | ERN1BRD4ATAD2BRD2BRD3 | |
| SCHEMBL16110425 | 0.80 | BRD4 (0.48) | ERN1BRD4ATAD2BRD2BRD3 | |
| SCHEMBL16140179 | 0.73 | BRD4 (0.64) | BRD4BRD2BRD3 | |
| SCHEMBL16110579 | 0.72 | ERN1 (0.56) | ERN1BRD4ATAD2BRD2BRD3 | |
| SCHEMBL16259169 | 0.71 | BRD4 (0.54) | ERN1BRD4BRD2 | |
| SCHEMBL16110759 | 0.69 | BRD4 (0.44) | ERN1BRD4ATAD2BRD2BRD3 | |
| SCHEMBL20362718 | 0.67 | BRD4 (0.49) | ERN1BRD4ATAD2BRD2BRD3 | |
| SCHEMBL9932071 | 0.67 | BRD4 (0.57) | ERN1BRD4BRD2BRD3 | |
| SCHEMBL16110198 | 0.67 | BRD4 (0.41) | ERN1BRD4ATAD2BRD2BRD3 | |
| SCHEMBL16225571 | 0.67 | BRD4 (0.64) | BRD4JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014182929-A1 | BENZIMIDAZOLE DERIVATIVES AS BROMODOMAIN INHIBITORS | GILEAD SCIENCES, INC. (US) | 2014-11-13 | — | — | WO | disclosed |