Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAE1 | Q13564 | 4/20 | 0.42 |
| ▸ | UBA3 | Q8TBC4 | 4/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | JAK3 | P52333 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | UBA6 | A0AVT1 | 1/20 | 0.34 |
| ▸ | ATG7 | O95352 | 1/20 | 0.34 |
| ▸ | UBA7 | P41226 | 1/20 | 0.34 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.34 |
| ▸ | FADS1 | O60427 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16262497 | 1.00 | NAE1 (0.42) | NAE1UBA3JAK2JAK3EGFR | |
| SCHEMBL2351017 | 1.00 | NAE1 (0.42) | NAE1UBA3JAK2JAK3EGFR | |
| SCHEMBL16262495 | 1.00 | NAE1 (0.42) | NAE1UBA3JAK2JAK3EGFR | |
| SCHEMBL782716 | 1.00 | NAE1 (0.42) | NAE1UBA3JAK2JAK3EGFR | |
| SCHEMBL783533 | 0.87 | NAE1 (0.40) | NAE1UBA3EGFRAURKARPS6KB1 | |
| SCHEMBL783581 | 0.85 | NAE1 (0.58) | NAE1UBA3UBA6ATG7UBA7 | |
| SCHEMBL16261758 | 0.85 | NAE1 (0.58) | NAE1UBA3UBA6ATG7UBA7 | |
| SCHEMBL783924 | 0.84 | NAE1 (0.40) | NAE1UBA3JAK2JAK3EGFR | |
| SCHEMBL783761 | 0.81 | ROCK1 (0.37) | NAE1UBA3PDPK1MAOAMAOB | |
| SCHEMBL782889 | 0.81 | ROCK1 (0.36) | NAE1UBA3PDPK1FADS1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8901136-B2 | Heteroaryl compounds useful as inhibitors of E1 activating enzymes | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2014-12-02 | — | — | US | disclosed |