Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 18/20 | 0.64 |
| ▸ | PIK3CA | P42336 | 14/20 | 0.57 |
| ▸ | PIK3CB | P42338 | 12/20 | 0.57 |
| ▸ | PIK3CG | P48736 | 11/20 | 0.57 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.56 |
| ▸ | PIK3R1 | P27986 | 10/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16667395 | 0.90 | PIK3CD (0.53) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R2 | |
| SCHEMBL16266146 | 0.87 | PIK3CD (0.74) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R2 | |
| SCHEMBL16266140 | 0.87 | PIK3CD (0.74) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R2 | |
| SCHEMBL461788 | 0.87 | PIK3CD (0.66) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R2 | |
| SCHEMBL659765 | 0.85 | PIK3CD (0.77) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R2 | |
| SCHEMBL19859026 | 0.85 | PIK3CD (0.81) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R2 | |
| SCHEMBL19859021 | 0.85 | PIK3CD (0.78) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R2 | |
| SCHEMBL13075809 | 0.84 | PIK3CD (0.64) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R2 | |
| SCHEMBL16667391 | 0.80 | PIK3CD (0.49) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R2 | |
| SCHEMBL19859027 | 0.80 | PIK3CD (0.91) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3260453-B1 | OXAZOLE SUBSTITUTED INDAZOLES AS PI3-KINASE INHIBITORS | GLAXO GROUP LTD (GB) | 2021-03-31 | — | — | EP | claimed |
| EP-2613781-B1 | INDAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF INFLUENZA VIRUS INFECTION | GLAXOSMITHKLINE IP DEV LTD (GB) | 2016-08-24 | — | — | EP | claimed |
| EP-2424864-B1 | OXAZOLE SUBSTITUTED INDAZOLES AS PI3-KINASE INHIBITORS | GLAXO GROUP LTD (GB) | 2014-12-03 | — | — | EP | claimed |