Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 18/20 | 0.69 |
| ▸ | ACE | P12821 | 9/20 | 0.69 |
| ▸ | MMEL1 | Q495T6 | 4/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18598040 | 0.91 | MME (0.70) | MMEACEMMEL1 | |
| SCHEMBL14891211 | 0.91 | MME (0.82) | MMEACEMMEL1 | |
| SCHEMBL14890588 | 0.91 | MME (0.70) | MMEACEMMEL1 | |
| SCHEMBL16011776 | 0.91 | MME (0.82) | MMEACEMMEL1 | |
| SCHEMBL18597739 | 0.91 | MME (0.82) | MMEACEMMEL1 | |
| SCHEMBL18783219 | 0.90 | MME (0.69) | MMEACEMMEL1 | |
| SCHEMBL16008239 | 0.90 | MME (0.80) | MMEACEMMEL1 | |
| SCHEMBL19708727 | 0.88 | MME (0.64) | MMEACEMMEL1 | |
| SCHEMBL14890709 | 0.85 | MME (0.79) | MMEACEMMEL1 | |
| SCHEMBL18597986 | 0.85 | MME (0.79) | MMEACEMMEL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8901169-B2 | Neprilysin inhibitors | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2014-12-02 | — | — | US | disclosed |
| US-8901169-B2 | Neprilysin inhibitors | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2014-12-02 | — | — | US | disclosed |