Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 19/20 | 0.80 |
| ▸ | KDR | P35968 | 2/20 | 0.65 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.65 |
| ▸ | KIT | P10721 | 1/20 | 0.65 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.65 |
| ▸ | FLT3 | P36888 | 1/20 | 0.65 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1184331 | 0.91 | PLK1 (0.78) | PLK1KDRPDGFRBKITFGFR1 | |
| SCHEMBL1183280 | 0.91 | PLK1 (0.78) | PLK1KDRPDGFRBKITFGFR1 | |
| SCHEMBL13892083 | 0.91 | PLK1 (0.91) | PLK1KDRPDGFRBKITFGFR1 | |
| SCHEMBL1185093 | 0.90 | PLK1 (0.82) | PLK1KDRPDGFRBKITFGFR1 | |
| SCHEMBL1890190 | 0.90 | PLK1 (0.81) | PLK1KDRPDGFRBKITFGFR1 | |
| SCHEMBL1185033 | 0.89 | PLK1 (0.85) | PLK1KDRPDGFRBKITFGFR1 | |
| SCHEMBL1183612 | 0.89 | PLK1 (0.76) | PLK1KDR | |
| SCHEMBL1183771 | 0.89 | PLK1 (0.76) | PLK1KDRPDGFRBKITFGFR1 | |
| SCHEMBL1879141 | 0.89 | PLK1 (1.00) | PLK1KDRPDGFRBKITFGFR1 | |
| SCHEMBL16270789 | 0.89 | PLK1 (0.80) | PLK1KDRPDGFRBKITFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799684-B1 | LACTAM COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | MILLENNIUM PHARM INC (US) | 2014-12-03 | — | — | EP | disclosed |