Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK5 | Q8IW41 | 18/20 | 0.62 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.62 |
| ▸ | MAPK14 | Q16539 | 17/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 16/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30514519 | 1.00 | MAPKAPK5 (0.62) | MAPKAPK5MAPKAPK2MAPK14MAPK1 | |
| SCHEMBL16280489 | 0.95 | MAPKAPK5 (0.69) | MAPKAPK5MAPKAPK2MAPK14MAPK1 | |
| SCHEMBL30514480 | 0.95 | MAPKAPK5 (0.69) | MAPKAPK5MAPKAPK2MAPK14MAPK1 | |
| SCHEMBL30514503 | 0.91 | MAPKAPK5 (0.61) | MAPKAPK5MAPKAPK2MAPK14MAPK1 | |
| SCHEMBL30514497 | 0.91 | MAPKAPK5 (0.75) | MAPKAPK5MAPKAPK2MAPK14MAPK1 | |
| SCHEMBL16279851 | 0.91 | MAPKAPK5 (0.61) | MAPKAPK5MAPKAPK2MAPK14MAPK1 | |
| SCHEMBL16280280 | 0.91 | MAPKAPK5 (0.75) | MAPKAPK5MAPKAPK2MAPK14MAPK1 | |
| SCHEMBL16279619 | 0.91 | MAPKAPK5 (0.76) | MAPKAPK5MAPKAPK2MAPK14MAPK1 | |
| SCHEMBL30514457 | 0.91 | MAPKAPK5 (0.76) | MAPKAPK5MAPKAPK2MAPK14MAPK1 | |
| SCHEMBL30514486 | 0.91 | MAPKAPK5 (0.57) | MAPKAPK5MAPKAPK2MAPK14MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3003039-B1 | METHYL/FLUORO-PYRIDINYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS AND FLUORO-PYRIMIDINYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | ACLARIS THERAPEUTICS INC (US) | 2021-02-24 | — | — | EP | claimed |
| US-9636333-B2 | Methyl/fluoro-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds and fluoro-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds | CONFLUENCE LIFE SCIENCES, INC. (US) | 2017-05-02 | — | — | US | claimed |
| EP-3003039-A1 | METHYL/FLUORO-PYRIDINYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS AND FLUORO-PYRIMIDINYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | Confluence Life Sciences, Inc. (US) | 2016-04-13 | — | — | EP | claimed |
| US-20150352092-A1 | METHYL/FLUORO-PYRIDINYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS AND FLUORO-PYRIMIDINYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | ACLARIS THERAPEUTICS, INC. | 2015-12-10 | — | — | US | claimed |
| US-9115089-B2 | Methyl/fluoro-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds and fluoro-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds | CONFLUENCE LIFE SCIENCES, INC. (US) | 2015-08-25 | — | — | US | claimed |
| US-20140364442-A1 | METHYL/FLUORO-PYRIDINYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS AND FLUORO-PYRIMIDINYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | ACLARIS THERAPEUTICS, INC. | 2014-12-11 | — | — | US | claimed |
| WO-2014197846-A1 | METHYL/FLUORO-PYRIDINYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS AND FLUORO-PYRIMIDINYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | CONFLUENCE LIFE SCIENCES, INC. (US) | 2014-12-11 | — | — | WO | claimed |
| US-20230242505-A1 | PROCESS, COMPOSITIONS, AND CRYSTALLINE FORMS OF SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | ACLARIS THERAPEUTICS, INC. | 2023-08-03 | — | — | US | disclosed |
| US-20230242505-A1 | PROCESS, COMPOSITIONS, AND CRYSTALLINE FORMS OF SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | ACLARIS THERAPEUTICS, INC. | 2023-08-03 | — | — | US | disclosed |
| US-20230242505-A1 | PROCESS, COMPOSITIONS, AND CRYSTALLINE FORMS OF SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | ACLARIS THERAPEUTICS, INC. | 2023-08-03 | — | — | US | disclosed |
| WO-2021195475-A1 | PROCESS, COMPOSITIONS, AND CRYSTALLINE FORMS OF SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | ACLARIS THERAPEUTICS, INC. (US) | 2021-09-30 | — | — | WO | disclosed |
| EP-3845529-A1 | METHYL/FLUORO-PYRIDINYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS AND FLUORO-PYRIMIDINYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | Aclaris Therapeutics, Inc. (US) | 2021-07-07 | — | — | EP | disclosed |
| EP-3845529-A1 | METHYL/FLUORO-PYRIDINYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS AND FLUORO-PYRIMIDINYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | Aclaris Therapeutics, Inc. (US) | 2021-07-07 | — | — | EP | disclosed |
| US-9115089-B2 | Methyl/fluoro-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds and fluoro-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds | CONFLUENCE LIFE SCIENCES, INC. (US) | 2015-08-25 | — | — | US | disclosed |
| US-9115089-B2 | Methyl/fluoro-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds and fluoro-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds | CONFLUENCE LIFE SCIENCES, INC. (US) | 2015-08-25 | — | — | US | disclosed |
| US-9115089-B2 | Methyl/fluoro-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds and fluoro-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds | CONFLUENCE LIFE SCIENCES, INC. (US) | 2015-08-25 | — | — | US | disclosed |
| US-20140364442-A1 | METHYL/FLUORO-PYRIDINYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS AND FLUORO-PYRIMIDINYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | ACLARIS THERAPEUTICS, INC. | 2014-12-11 | — | — | US | disclosed |
| US-20140364442-A1 | METHYL/FLUORO-PYRIDINYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS AND FLUORO-PYRIMIDINYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | ACLARIS THERAPEUTICS, INC. | 2014-12-11 | — | — | US | disclosed |
| WO-2014197846-A1 | METHYL/FLUORO-PYRIDINYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS AND FLUORO-PYRIMIDINYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | CONFLUENCE LIFE SCIENCES, INC. (US) | 2014-12-11 | — | — | WO | disclosed |
| US-20140364442-A1 | METHYL/FLUORO-PYRIDINYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS AND FLUORO-PYRIMIDINYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | ACLARIS THERAPEUTICS, INC. | 2014-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230242505-A1 | PROCESS, COMPOSITIONS, AND CRYSTALLINE FORMS OF SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | MAPK6, MAPK1, MAPK8 | MAPKAPK5 47/4885MAPKAPK2 44/4885MAPK14 38/4885 |
| US-20150352092-A1 | METHYL/FLUORO-PYRIDINYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS AND FLUORO-PYRIMIDINYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | MAPK1, MAP3K1, MAPK6 | MAPKAPK5 35/4885MAPKAPK2 32/4885MAPK14 40/4885 |
| US-20140364442-A1 | METHYL/FLUORO-PYRIDINYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS AND FLUORO-PYRIMIDINYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | MAPK1, MAP3K1, MAPK6 | MAPKAPK5 35/4885MAPKAPK2 32/4885MAPK14 40/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.