Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TACR1 | P25103 | 4/20 | 0.44 |
| ▸ | GRK2 | P25098 | 1/20 | 0.42 |
| ▸ | CASP6 | P55212 | 1/20 | 0.42 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.40 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.40 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.40 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12160763 | 1.00 | RXFP1 (0.49) | RXFP1SMN1; SMN2TACR1GRK2CASP6 | |
| SCHEMBL2583638 | 1.00 | RXFP1 (0.49) | RXFP1SMN1; SMN2TACR1GRK2CASP6 | |
| SCHEMBL29726766 | 0.90 | RXFP1 (0.44) | RXFP1SMN1; SMN2GRK2CASP6CASP8 | |
| SCHEMBL16280642 | 0.90 | RXFP1 (0.44) | RXFP1SMN1; SMN2GRK2CASP6CASP8 | |
| SCHEMBL2567672 | 0.90 | RXFP1 (0.44) | RXFP1SMN1; SMN2GRK2CASP6CASP8 | |
| SCHEMBL20426001 | 0.90 | RXFP1 (0.44) | RXFP1SMN1; SMN2GRK2CASP6CASP8 | |
| SCHEMBL12160774 | 0.90 | RXFP1 (0.44) | RXFP1SMN1; SMN2GRK2CASP6CASP8 | |
| SCHEMBL29726747 | 0.81 | RXFP1 (0.50) | RXFP1SMN1; SMN2GRK2CASP6CASP8 | |
| SCHEMBL18801716 | 0.81 | RXFP1 (0.50) | RXFP1SMN1; SMN2GRK2CASP6CASP8 | |
| SCHEMBL12160788 | 0.81 | RXFP1 (0.50) | RXFP1SMN1; SMN2GRK2CASP6CASP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180179160-A1 | C5AR ANTAGONISTS | CHEMOCENTRYX, INC. | 2018-06-28 | — | — | US | disclosed |
| US-8906938-B2 | C5aR antagonists | CHEMOCENTRYX, INC. (US) | 2014-12-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180179160-A1 | C5AR ANTAGONISTS | C5AR1, C5AR2, C3AR1 | RXFP1 911/4885SMN1; SMN2 2376/4885TACR1 97/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.