Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 1/20 | 0.43 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.40 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.40 |
| ▸ | ITGAV | P06756 | 1/20 | 0.40 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.40 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18801708 | 1.00 | PREP (0.43) | PREPITGB3ITGB1ITGAVITGA5 | |
| SCHEMBL3341716 | 1.00 | PREP (0.43) | PREPITGB3ITGB1ITGAVITGA5 | |
| SCHEMBL3341710 | 1.00 | PREP (0.43) | PREPITGB3ITGB1ITGAVITGA5 | |
| SCHEMBL3341723 | 1.00 | PREP (0.43) | PREPITGB3ITGB1ITGAVITGA5 | |
| SCHEMBL25432711 | 0.91 | PREP (0.45) | PREPITGB3ITGB1ITGAVITGA5 | |
| SCHEMBL15065340 | 0.91 | PREP (0.45) | PREPITGB3ITGB1ITGAVITGA5 | |
| Oxalic Acid SCHEMBL25431331 | 0.91 | PREP (0.44) | PREPITGB3ITGB1ITGAVITGA5 | |
| SCHEMBL16280637 | 0.87 | CNR2 (0.51) | PREPKMT2AHCRTR1HCRTR2MEN1 | |
| SCHEMBL18609681 | 0.87 | CNR2 (0.51) | PREPKMT2AHCRTR1HCRTR2MEN1 | |
| SCHEMBL12160754 | 0.87 | CNR2 (0.51) | PREPKMT2AHCRTR1HCRTR2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8906938-B2 | C5aR antagonists | CHEMOCENTRYX, INC. (US) | 2014-12-09 | — | — | US | disclosed |