Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 20/20 | 1.00 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.65 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16280705 | 0.86 | DPP4 (1.00) | DPP4OPRM1OPRK1 | |
| SCHEMBL16280714 | 0.82 | DPP4 (0.69) | DPP4OPRM1OPRK1 | |
| SCHEMBL389336 | 0.82 | DPP4 (1.00) | DPP4OPRM1OPRK1 | |
| SCHEMBL389335 | 0.82 | DPP4 (1.00) | DPP4OPRM1OPRK1 | |
| SCHEMBL28533329 | 0.82 | DPP4 (0.80) | DPP4OPRM1OPRK1 | |
| SCHEMBL27843651 | 0.81 | DPP4 (1.00) | DPP4OPRM1OPRK1 | |
| Alogliptin SCHEMBL17036596 | 0.79 | DPP4 (1.00) | DPP4OPRM1OPRK1 | |
| Alogliptin SCHEMBL29352995 | 0.79 | DPP4 (1.00) | DPP4OPRM1OPRK1 | |
| Alogliptin SCHEMBL121028 | 0.79 | DPP4 (1.00) | DPP4OPRM1OPRK1 | |
| Alogliptin SCHEMBL174188 | 0.79 | DPP4 (1.00) | DPP4OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2680851-B1 | FUSED BICYCLIC HETEROCYCLES USEFUL AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS | MERCK SHARP & DOHME (US) | 2016-08-17 | — | — | EP | disclosed |
| US-8907086-B2 | Fused bicyclic heterocycles useful as dipeptidyl peptidase-IV inhibitors | MERCK SHARP & DOHME CORP. (US) | 2014-12-09 | — | — | US | disclosed |
| US-8907086-B2 | Fused bicyclic heterocycles useful as dipeptidyl peptidase-IV inhibitors | MERCK SHARP & DOHME CORP. (US) | 2014-12-09 | — | — | US | disclosed |