Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Serlopitant. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 known ✓ | P25103 | 20/20 | 1.00 |
| ▸ | TACR2 | P21452 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | CYP2C8 | P10632 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 1/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | TACR3 | P29371 | 1/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 1/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.58 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Serlopitant SCHEMBL3183159 | 1.00 | TACR1 (1.00) | TACR1TACR2CYP3A4CYP2C8CYP2D6 | |
| Serlopitant SCHEMBL16333766 | 1.00 | TACR1 (1.00) | TACR1TACR2CYP3A4CYP2C8CYP2D6 | |
| Serlopitant SCHEMBL12646287 | 1.00 | TACR1 (1.00) | TACR1TACR2CYP3A4CYP2C8CYP2D6 | |
| Serlopitant SCHEMBL24067973 | 1.00 | TACR1 (1.00) | TACR1TACR2CYP3A4CYP2C8CYP2D6 | |
| Serlopitant SCHEMBL3184271 | 1.00 | TACR1 (1.00) | TACR1TACR2CYP3A4CYP2C8CYP2D6 | |
| Serlopitant SCHEMBL23883105 | 1.00 | TACR1 (1.00) | TACR1TACR2CYP3A4CYP2C8CYP2D6 | |
| Serlopitant SCHEMBL16280736 | 1.00 | TACR1 (1.00) | TACR1TACR2CYP3A4CYP2C8CYP2D6 | |
| SCHEMBL13531608 | 0.95 | TACR1 (0.91) | TACR1TACR2CYP3A4CYP2C8CYP2D6 | |
| SCHEMBL16280639 | 0.95 | TACR1 (0.91) | TACR1TACR2CYP3A4CYP2C8CYP2D6 | |
| SCHEMBL16353223 | 0.95 | TACR1 (0.91) | TACR1TACR2CYP3A4CYP2C8CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8906951-B1 | Use of NK-1 receptor antagonists in pruritus | Tigercat Pharma, Inc. (US) | 2014-12-09 | — | — | US | disclosed |