Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 19/20 | 0.60 |
| ▸ | CNR2 | P34972 | 15/20 | 0.60 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.45 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.45 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.45 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.45 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.45 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.45 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1628012 | 0.89 | CNR1 (0.62) | CNR1CNR2GABRA1GABRB1GABRA5 | |
| SCHEMBL1628719 | 0.83 | CNR1 (0.62) | CNR1CNR2GABRA1GABRB1GABRA5 | |
| SCHEMBL1627687 | 0.83 | CNR1 (0.62) | CNR1CNR2GABRA1GABRB1GABRA5 | |
| SCHEMBL5750442 | 0.81 | CNR1 (0.72) | CNR1CNR2GABRA1GABRB1GABRA5 | |
| SCHEMBL5249113 | 0.76 | CNR1 (0.82) | CNR1CNR2GABRA1GABRB1GABRA5 | |
| SCHEMBL5747412 | 0.76 | CNR1 (0.54) | CNR1CNR2GABRA1GABRB1GABRA5 | |
| SCHEMBL1628010 | 0.75 | CNR1 (1.00) | CNR1CNR2GABRA1GABRB1GABRA5 | |
| SCHEMBL5247000 | 0.75 | CNR1 (1.00) | CNR1CNR2GABRA1GABRB1GABRA5 | |
| SCHEMBL1629575 | 0.75 | CNR1 (0.63) | CNR1CNR2 | |
| SCHEMBL1628617 | 0.74 | CNR1 (0.63) | CNR1CNR2GABRA1GABRB1GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4667867-B2 | — | — | 2011-04-13 | — | — | JP | claimed |
| EP-1558252-A4 | SUBSTITUTED FURO 2,3-B| PYRIDINE DERIVATIVES | MERCK & CO INC (US) | 2006-05-17 | — | — | EP | claimed |
| JP-2005538120-A | — | — | 2005-12-15 | — | — | JP | claimed |
| EP-1558252-A2 | SUBSTITUTED FURO 2,3-B] PYRIDINE DERIVATIVES | Merck & Co., Inc. (US) | 2005-08-03 | — | — | EP | claimed |
| WO-2004012671-A2 | SUBSTITUTED FURO [2,3-B] PYRIDINE DERIVATIVES | MERCK & CO., INC. (US) | 2004-02-12 | — | — | WO | claimed |