Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 8/20 | 0.46 |
| ▸ | CCND1 | P24385 | 8/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.46 |
| ▸ | CDK9 | P50750 | 2/20 | 0.46 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.46 |
| ▸ | CDK11A | Q9UQ88 | 2/20 | 0.46 |
| ▸ | CCND2 | P30279 | 5/20 | 0.42 |
| ▸ | CCND3 | P30281 | 5/20 | 0.42 |
| ▸ | BRD4 | O60885 | 2/20 | 0.41 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 3/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | CTSC | P53634 | 2/20 | 0.40 |
| ▸ | WEE1 | P30291 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16285701 | 0.92 | CDK4 (0.47) | CDK4CCND1CCNT1CDK9CDK6 | |
| SCHEMBL16285705 | 0.88 | CDK4 (0.44) | CDK4CCND1CCNT1CDK9CDK6 | |
| SCHEMBL16285694 | 0.88 | WEE1 (0.46) | CDK4CCND1CCND2CCND3CTSC | |
| SCHEMBL16285707 | 0.88 | CDK4 (0.44) | CDK4CCND1CCNT1CDK9CDK6 | |
| SCHEMBL16286126 | 0.86 | CDK4 (0.44) | CDK4CCND1CCNT1CDK9CDK6 | |
| SCHEMBL16285703 | 0.86 | CDK4 (0.42) | CDK4CCND1CCNT1CDK9CDK6 | |
| SCHEMBL16285704 | 0.86 | CDK4 (0.42) | CDK4CCND1CCND2CCND3BRD4 | |
| SCHEMBL16285699 | 0.83 | CDK4 (0.46) | CDK4CCND1CCNT1CDK9CDK6 | |
| SCHEMBL16285720 | 0.83 | CDK4 (0.44) | CDK4CCND1CCNT1CDK9CDK6 | |
| SCHEMBL10192698 | 0.82 | CDK4 (0.65) | CDK4CCND1CCND2CCND3EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140364430-A1 | METHODS FOR TREATING SCHIZOPHRENIA | AFRAXIS HOLDINGS INC (US) | 2014-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140364430-A1 | METHODS FOR TREATING SCHIZOPHRENIA | GRIN2A, GRIN2C, GRIN3A | CDK4 2824/4885CCND1 4822/4885CCNT1 4745/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.